Tuesday, December 31, 2019

Addressing Controversial Food Claims with Patients


Addressing Controversial Food Claims with Patients


The internet has had a resounding impact on human health. There is so much information at our fingertips but unless you are an authority interpretation of what we read in the media is open to debate. Since I am a nutritionist my patients are quite curious around commentaries that imply soybeans cause breast cancer, that gluten causes Alzheimer’s disease, that ketogenic diets are an ideal weight loss strategy, etc. I have been challenged to explain these controversial claims in simple terms but after a few iterations, I’ve come up with a three-pronged approach that is both effective and appreciated:
2.       Discuss the potential consequences of the claim
3.       Provide alternative recommendations

I first start by explaining the science behind the headline. Sometimes the claim is derived solely from experiments conducted in test-tubes or in rodents. These data often do not translate to humans, or, translation studies have yet to be preformed.

For example, the relationship between soy and cancer stems from studies with a breast cancer cell line. These experiments showed that the phytochemical in soybeans, genistein, increases the growth of MCF7 cells at low concentrations but inhibits their growth at high concentrations. Several meta-analyses looking at outcomes in humans have shown that soybean consumption not only reduces the risk of breast cancer, but it also reduces rates of reoccurrence of breast cancer and increases lifespan in breast cancer patients.

Calorie restriction is another hot button topic that purports extended lifespan when calorie consumption is limited. This theory has only been documented in cell lines, rodents, and monkeys, and has yet to be proven in humans. I have a strong opinion regarding calorie restriction in that I do not allow any of my patients to consume fewer calories than their metabolism will support which is typically 1,500 calories for women and 2,000 calories for men.

I then explain the physical consequences of following through on these types of claims. Eliminating entire food groups is rarely a good idea. A large percentage of my patient population is interested in testing out, for example, a ketogenic diet for weight loss or a Paleo diet if they suffer from an autoimmune condition. Following a ketogenic diet, where 70 to 80 percent of your calories are derived from fats, is a short-term strategy that will produce short term results. Tricking the body into using fats instead of glucose for energy will starve the body of fiber and critical nutrients such as folate (B9), biotin (B7), selenium, choline, vitamins A, E, and D, chromium, iodine, and magnesium, leading to malnutrition and a wicked case of constipation. Furthermore, compliance among my weight loss patients following a ketogenic diet is zero percent.

Exclusions in the Paleo diet include whole grains, legumes, and dairy, which lead to deficiencies of B vitamins, calcium and vitamin D. These deficiencies alone greatly increase the risk of osteoporosis. Although these gaps may be corrected with supplements, the body assimilates nutrients best from foods that dilute and disperse among other substances that facilitate their absorption and use by the body.

I am currently working with a young mother, diagnosed with Graves’ disease, who is still nursing her son. She has been strictly following a Paleo diet to alleviate her hyperthyroid symptoms. Her condition has not improved and she risks a calcium and vitamin D deficiency, which could be detrimental for both the mother and her baby.

As a former pharmacologist who has developed drugs for just about every therapeutic indication you can think of, I’d like to point out that medicines are nothing more than nutrients that are structurally modified to make them more potent than their original form. Medicines are used therapeutically to correct chemical deficiencies. Food, on the other hand, is used for disease prevention and health maintenance. Looked at another way, food truly is medicine, and if you do not get enough nutrients from food then medicine will become your food.

Fresh food contains all the nutrients you need in just the right concentration that nature intended. Pharmaceutical “nutrients” are at least 10,000 times more potent than the nutrient from which they are derived. This increase in potency increases risk of off-target activity and subsequent side-effects. Over-eating is akin to a nutrient overdose, which also has side-affects, including bloating, gas, diarrhea, and heart burn.

Finally, after explaining the controversy and consequences, I provide my patients with an alternative recommendation. I cannot think of any better dietary strategy then a Mediterranean diet, which does not eliminate any food group. This meal plan focuses on consumption of fruits, vegetables, and whole grains with modest consumption of animal protein and healthy fats that include avocados, olive oil, nuts and seeds. A Mediterranean diet has been clinically proven to reduce all-cause disease risk and to increase lifespan when routinely followed.

For patients who are concerned about food sensitivity, I offer blood testing that measures immunoglobulin levels produced in response to 96 different food antigens. If a bona fide food allergy is suspected, then I refer my patients to a reputable immunologist.

I welcome my colleagues and all members of the nutrition community to adopt these three useful strategies for answering patient concerns around food, explaining the controversy, discussing the consequences, and providing alternative recommendations based on scientific data. I have found that this increases compliance with my suggested guidance and prevents patients from following ideas that may not be beneficial to their health.


References
Crous-Bou, M., Fung, T.T., Prescott, J., Julin, B.,  Du, M., Sun, Q., Rexrode, K.M., Hu, F.B., and De Vivo, I. (2014) Mediterranean diet and telomere length in Nurses’ Health Study: population based cohort study. BMJ (Clinical research ed.). Retrieved from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4252824/

Jacobs D.R. Jr., Gross, M.D., and Tapsell, L.C. (2009) Food synergy: an operational concept for understanding nutrition. American Journal of Clinical Nutrition. Retrieved from: https://www.ncbi.nlm.nih.gov/pubmed/19279083

Pons, D.G., Nadal-Serrano, M., Torrens-Mas, M., Oliver, J., and Roca, P. (2016) The Phytoestrogen Genistein Affects Breast Cancer Cells Treatment Depending on the ERα/ERβ Ratio. Journal of Cellular Biochemisty. Retrieved from:  https://www.ncbi.nlm.nih.gov/pubmed/26100284

Sizer, F.S., Whitney, E. N. (2017) Nutrition: Concepts and Controversies 14th Edition. Cengage Learning

Shu, X.O., Zheng, Y., Cai, H., Gu, K., Chen, Z., Zheng, W., and Lu, W. (2009) Soy food intake and breast cancer survival. JAMA. Retrieved from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2874068/



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